Recurrent Fetal Loss and Antiphospholipid Antibodies: Clinical and Therapeutic Aspects

نویسندگان

  • O. Blétry
  • A.-M. Piette
چکیده

Recurrent fetal losses indicate screening for antiphospholipid antibodies, especially after the third consecutive fetal loss, or when they occur after 12 weeks gestation or when the mother presents with thrombosis or other ailments of antiphospholipid syndrome. Fetal loss may be caused by thromboses of placental vasculature. There is no agreement concerning the mechanism of thromboses: protein C pathway and/or annexin V are the best candidates. When fetal loss occurs early during gestation, murine models suggest that antiphospholipid antibodies can also act on trophoblasts by inhibiting syncytia formation. Among the high risk patients with more than two fetal losses, an association of aspirin and heparin given early during gestation is successful in 70-80% of cases.

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نشانگان آنتی فسفولیپید

Antiphospholipid syndrome is an autoimmune condition characterized by recurrent vascular thrombosis, pregnancy loss and thrombocytopenia associated with moderate to high levels of antiphospholipid antibodies. Most of clinical features are results of thrombotic phenomena. The pathophysiologic basis ot this syndrome is still unknown. the diagnosis of this syndrome is made by combination of clinic...

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Management of antiphospholipid antibody syndrome: a systematic review.

CONTEXT Antiphospholipid antibodies are autoantibodies directed against proteins that bind to phospholipid. Antiphospholipid antibody syndrome (APS) refers to the association between antiphospholipid antibodies and thrombosis risk or pregnancy morbidity. Patients with APS may be at increased risk of recurrent arterial or venous thrombosis or pregnancy loss. OBJECTIVE To systematically review ...

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عنوان ژورنال:
  • Infectious Diseases in Obstetrics and Gynecology

دوره 5  شماره 

صفحات  -

تاریخ انتشار 1997